TEMPO-derived spin labels linked to the nucleobases adenine and cytosine for probing local structural perturbations in DNA by EPR spectroscopy

TEMPO-derived spin labels linked to the nucleobases adenine and cytosine for probing local structural perturbations in DNA by EPR spectroscopy

Three 2´-deoxynucleosides containing semi-flexible spin labels, namely TA, UA and UC, were prepared and incorporated into deoxyoligonucleotides using the phosphoramidite method. All three nucleosides contain 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) connected to the exocyclic amino group; TA dire...

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Bibliographic Details
Main Authors: Dnyaneshwar B. Gophane, Snorri Th. Sigurdsson
Format: Article
Language:English
Published: Beilstein-Institut 2015-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
aminoxyl radical
ESR spectroscopy
nitroxide
nucleic acids
site-directed spin labeling (SDSL)
spin labels
structure-dependent dynamics
Online Access:https://doi.org/10.3762/bjoc.11.24

Internet

https://doi.org/10.3762/bjoc.11.24

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