A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines

Abstract Background Increased flux through both glycolytic and oxidative metabolic pathways is a hallmark of breast cancer cells and is critical for their growth and survival. As such, targeting this metabolic reprograming has received much attention as a potential treatment approach. However, the h...

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Bibliographic Details
Main Authors: Sheree D. Martin, Sean L. McGee
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cancer & Metabolism
Subjects:
Online Access:https://doi.org/10.1186/s40170-019-0207-x