Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse

Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse

Mitochondrial dysfunction causes a range of early-onset neurological diseases and contributes to neurodegenerative conditions. The mechanisms of neurological damage however are poorly understood, as accessing relevant tissue from patients is difficult, and appropriate models are limited. Hence, we...

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Bibliographic Details
Main Authors: Matthew J. Bird, Xiaonan W. Wijeyeratne, Jasper C. Komen, Adrienne Laskowski, Michael T. Ryan, David R. Thorburn, Ann E. Frazier
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-11-01
Series:Bioscience Reports
Subjects:
metabolic stress
mitochondrial disease
mouse models
neuropathology
primary cells
reactive oxygen species
Online Access:http://www.bioscirep.org/bsr/034/e151/bsr034e151.htm

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