Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia

Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia

In preeclampsia, widespread maternal endothelial dysfunction is often secondary to excessive generation of placental-derived anti-angiogenic factors, including soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), along with proinflammatory cytokines such as tumour necrosis factor...

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Bibliographic Details
Main Authors: Rahana Abd Rahman, Padma Murthi, Harmeet Singh, Seshini Gurungsinghe, Bryan Leaw, Joanne C. Mockler, Rebecca Lim, Euan M. Wallace
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
hydroxychloroquine
preeclampsia
sFlt-1
sEng
TNF-α
endothelial dysfunction
Online Access:https://www.mdpi.com/1422-0067/21/7/2504

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https://www.mdpi.com/1422-0067/21/7/2504

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