Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target

Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target

Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington’s disease (HD), Alzheimer’s disease (AD), P...

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Bibliographic Details
Main Authors: Allison R. Peterson, Devin K. Binder
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GLT-1
palmitoylation
S-nitrosylation
sumoylation
ubiquitination
post-translational modifications
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00164/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00164/full

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