Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses

Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses

Vaccines intended to induce a cytotoxic CD8+ T-cell response are highly sought after. However, some of these vaccines can be problematic if they replicate in the host. An alternative strategy is to exploit cross-presentation of exogenous antigens to express peptides on major histocompatibility compl...

Full description

Bibliographic Details
Main Authors: Julia Kim, Vandana Gambhir, Attiya Alatery, Sameh Basta
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2010/218752
id doaj-2482ca6353f044fbacc8f9a30340c2e3
record_format Article
spelling doaj-2482ca6353f044fbacc8f9a30340c2e32020-11-25T00:50:44ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512010-01-01201010.1155/2010/218752218752Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte ResponsesJulia Kim0Vandana Gambhir1Attiya Alatery2Sameh Basta3Department of Microbiology and Immunology, Queen's University, Kingston, ON, K7L 3N6, CanadaDepartment of Microbiology and Immunology, Queen's University, Kingston, ON, K7L 3N6, CanadaDepartment of Microbiology and Immunology, Queen's University, Kingston, ON, K7L 3N6, CanadaDepartment of Microbiology and Immunology, Queen's University, Kingston, ON, K7L 3N6, CanadaVaccines intended to induce a cytotoxic CD8+ T-cell response are highly sought after. However, some of these vaccines can be problematic if they replicate in the host. An alternative strategy is to exploit cross-presentation of exogenous antigens to express peptides on major histocompatibility complex (MHC) class I molecules. During cross-presentation, the delivered exogenous antigen can be taken up and processed through diverse mechanisms. Here, we will discuss the recent advances regarding the complex nature of the cross-priming process and the models that reflect its relevance in vivo. Moreover, we summarize current data that explore potential adjuvants and vaccine vectors that deliver antigens to activate CD8+ T cells relying on cross-presentation.http://dx.doi.org/10.1155/2010/218752
collection DOAJ
language English
format Article
sources DOAJ
author Julia Kim
Vandana Gambhir
Attiya Alatery
Sameh Basta
spellingShingle Julia Kim
Vandana Gambhir
Attiya Alatery
Sameh Basta
Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses
Journal of Biomedicine and Biotechnology
author_facet Julia Kim
Vandana Gambhir
Attiya Alatery
Sameh Basta
author_sort Julia Kim
title Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses
title_short Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses
title_full Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses
title_fullStr Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses
title_full_unstemmed Delivery of Exogenous Antigens to Induce Cytotoxic CD8+ T Lymphocyte Responses
title_sort delivery of exogenous antigens to induce cytotoxic cd8+ t lymphocyte responses
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2010-01-01
description Vaccines intended to induce a cytotoxic CD8+ T-cell response are highly sought after. However, some of these vaccines can be problematic if they replicate in the host. An alternative strategy is to exploit cross-presentation of exogenous antigens to express peptides on major histocompatibility complex (MHC) class I molecules. During cross-presentation, the delivered exogenous antigen can be taken up and processed through diverse mechanisms. Here, we will discuss the recent advances regarding the complex nature of the cross-priming process and the models that reflect its relevance in vivo. Moreover, we summarize current data that explore potential adjuvants and vaccine vectors that deliver antigens to activate CD8+ T cells relying on cross-presentation.
url http://dx.doi.org/10.1155/2010/218752
work_keys_str_mv AT juliakim deliveryofexogenousantigenstoinducecytotoxiccd8tlymphocyteresponses
AT vandanagambhir deliveryofexogenousantigenstoinducecytotoxiccd8tlymphocyteresponses
AT attiyaalatery deliveryofexogenousantigenstoinducecytotoxiccd8tlymphocyteresponses
AT samehbasta deliveryofexogenousantigenstoinducecytotoxiccd8tlymphocyteresponses
_version_ 1725246737488019456

Similar Items