Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

The mammalian unfolded protein response (UPR) is propagated by three ER-resident transmembrane proteins, each of which initiates a signaling cascade that ultimately culminates in production of a transcriptional activator. The UPR was originally characterized as a pathway for upregulating ER chaperon...

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Bibliographic Details
Main Authors: Angela eArensdorf, Danilo eDiedrichs, Thomas eRutkowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Genetics
Subjects:
Transcription Factors
er stress
mRNA stability
gene regulatory networks (GRN)
unfolded protein response (UPR)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00256/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00256/full

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