Berberine Protects Against Simulated Ischemia/Reperfusion Injury-Induced H9C2 Cardiomyocytes Apoptosis In Vitro and Myocardial Ischemia/Reperfusion-Induced Apoptosis In Vivo by Regulating the Mitophagy-Mediated HIF-1α/BNIP3 Pathway

Berberine Protects Against Simulated Ischemia/Reperfusion Injury-Induced H9C2 Cardiomyocytes Apoptosis In Vitro and Myocardial Ischemia/Reperfusion-Induced Apoptosis In Vivo by Regulating the Mitophagy-Mediated HIF-1α/BNIP3 Pathway

Berberine (BBR) has a variety of pharmacological activities and is widely used in Asian countries. However, the clinical application of BBR still lacks scientific basis, what protective mechanism of BBR against myocardial ischemia-reperfusion injury (MIRI). In vitro experiments, BBR pretreatment reg...

Full description

Bibliographic Details
Main Authors: Na Zhu, Jiang Li, Yongli Li, Yuwei Zhang, Qiubo Du, Peiyuan Hao, Jinying Li, Xueming Cao, Li Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
berberine
myocardial ischemia injury
myocardial reperfusion injury
mitophagy
HIF-1α/BNIP3 pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00367/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00367/full

Similar Items