Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study.

BACKGROUND:The metabolic basis of Alzheimer disease (AD) pathology and expression of AD symptoms is poorly understood. Omega-3 and -6 fatty acids have previously been linked to both protective and pathogenic effects in AD. However, to date little is known about how the abundance of these species is...

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Bibliographic Details
Main Authors: Stuart G Snowden, Amera A Ebshiana, Abdul Hye, Yang An, Olga Pletnikova, Richard O'Brien, John Troncoso, Cristina Legido-Quigley, Madhav Thambisetty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC5360226?pdf=render