Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber’s Hereditary Optic Neuropathy Cells

Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber’s Hereditary Optic Neuropathy Cells

Here we have collected evidence suggesting that chronic changes in the NO homeostasis and the rise of reactive oxygen species bioavailability can contribute to cell dysfunction in Leber’s hereditary optic neuropathy (LHON) patients. We report that peripheral blood mononuclear cells (PBMCs), derived...

Full description

Bibliographic Details
Main Authors:	Micol Falabella, Elena Forte, Maria Chiara Magnifico, Paolo Santini, Marzia Arese, Alessandro Giuffrè, Kristina Radić, Luciana Chessa, Giulia Coarelli, Maria Chiara Buscarinu, Rosella Mechelli, Marco Salvetti, Paolo Sarti
Format:	Article
Language:	English
Published:	Hindawi Limited 2016-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2016/3187560

Similar Items

Two detrimental mutations in cattle mitogenome indicate the presence of Leber's hereditary optic neuropathy
by: Dinko Novosel, et al.
Published: (2019-03-01)

The Chemical Interplay between Nitric Oxide and Mitochondrial Cytochrome c Oxidase: Reactions, Effectors and Pathophysiology
by: Paolo Sarti, et al.
Published: (2012-01-01)

Neuropatía óptica hereditaria de Leber Leber´s hereditary optic neuropathy
by: Yannara Elina Columbié Garbey, et al.
Published: (2012-06-01)

Leber hereditary optic neuropathy: current perspectives
by: Meyerson C, et al.
Published: (2015-06-01)

The Elusive Pathophysiology of Leber's Hereditary Optic Neuropathy
by: Kaitlin Kogachi, et al.
Published: (2016-09-01)

Leber’s hereditary optic neuropathy - case report
by: Mirjana A. Janicijevic Petrovic, et al.
Published: (2012-09-01)

Leber’s hereditary optic neuropathy - case report
by: Mirjana A. Janicijevic Petrovic, et al.
Published: (2012-09-01)

Secondary post-geniculate involvement in Leber's hereditary optic neuropathy.
by: Giovanni Rizzo, et al.
Published: (2012-01-01)

La neuropatia ottica ereditaria di Leber (Leber Hereditary Optic Neuropathy, LHON)
by: Maria Lucia Cascavilla
Published: (2017-02-01)

New Evidence for Cross Talk between Melatonin and Mitochondria Mediated by a Circadian-Compatible Interaction with Nitric Oxide
by: Marzia Arese, et al.
Published: (2013-05-01)

Use of Idebenone for the Treatment of Leber’s Hereditary Optic Neuropathy
by: Claudia B. Catarino MD, PhD, et al.
Published: (2017-09-01)

Leber's Hereditary Optic Neuropathy: A Case Report
by: Chi-Wu Chang, et al.
Published: (2003-10-01)

Leber’s Hereditary Optic Neuropathy: a Case Report
by: R. Daneshvar Kakhki
Published: (2017-02-01)

Antiretroviral therapy-induced Leber’s hereditary optic neuropathy
by: Anand Moodley, et al.
Published: (2014-05-01)

Leber Hereditary Optic Neuropathy: Review of Treatment and Management
by: Rabih Hage, et al.
Published: (2021-05-01)

Leber’s Hereditary Optic Neuropathy. A Clinical Case
by: O. I. Karushin, et al.
Published: (2018-10-01)

Leber's Hereditary Optic Neuropathy: A Report on Novel mtDNA Pathogenic Variants
by: Lorenzo Peverelli, et al.
Published: (2021-06-01)

Leber's hereditary optic neuropathy: Shifting our attention to the macula
by: Samuel Asanad, et al.
Published: (2019-03-01)

The Genetics of Leber’s Hereditary Optic Neuropathy: A Literature Review
by: Henry Liu
Published: (2018-11-01)

Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy
by: Agaath Hedina Manickam, et al.
Published: (2017-01-01)

Nationwide epidemiological survey of Leber hereditary optic neuropathy in Japan
by: Kaori Ueda
Published: (2017-09-01)

Leber's hereditary optic neuropathy: case report and literature review
by: Hélio Afonso Ghizoni Teive, et al.

Molecular epidemiology of Leber hereditary optic neuropathy in Xingtai China
by: Shi-Peng Xie, et al.
Published: (2016-04-01)

Renal artery aneurysm associated with Leber hereditary optic neuropathy
by: Ruth Ellen Jones, MD, et al.
Published: (2018-03-01)

Leber’s hereditary optic neuropathy is multiorgan not mono-organ
by: Finsterer J, et al.
Published: (2016-11-01)

Progress of the factors influencing the penetrance of Leber's hereditary optic neuropathy
by: Jun-Wei Zhong, et al.
Published: (2015-11-01)

Childhood-Onset Leber Hereditary Optic Neuropathy: Particular Features
by: Cunha AM, et al.
Published: (2021-03-01)

Nonylphenol and Octylphenol Differently Affect Cell Redox Balance by Modulating the Nitric Oxide Signaling
by: Maria Chiara Magnifico, et al.
Published: (2018-01-01)

Cardiovascular Mitochondrial Dysfunction Induced by Cocaine: Biomarkers and Possible Beneficial Effects of Modulators of Oxidative Stress
by: Manuela Graziani, et al.
Published: (2017-01-01)

Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside
by: Rajeshwari D. Koilkonda, et al.
Published: (2011-01-01)

Neuromyelitis optica antibody in Leber hereditary optic neuropathy: case report
by: Luciano Mesquita Simão
Published: (2012-08-01)

Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.
by: Maria A Rocca, et al.
Published: (2011-02-01)

Molecular Investigation of Leber’s Hereditary Optic Neuropathy Common Mutations in Suspected Patients
by: HR Soleimanpour, et al.
Published: (2004-08-01)

Molecular Investigation of Leber’s Hereditary Optic Neuropathy Common Mutations in Suspected Patients
by: HR Soleimanpour, et al.
Published: (2004-09-01)

Increased Protein <i>S</i>-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON)
by: Lei Zhou, et al.
Published: (2020-04-01)

Whole Mitochondrial Genome Analysis in Serbian Cases of Leber’s Hereditary Optic Neuropathy
by: Phepy G. A. Dawod, et al.
Published: (2020-09-01)

Long-term outcomes of gene therapy for the treatment of Leber's hereditary optic neuropathy
by: Shuo Yang, et al.
Published: (2016-08-01)

Rare primary mitochondrial DNA mutations and probable synergistic variants in Leber's hereditary optic neuropathy.
by: Alessandro Achilli, et al.
Published: (2012-01-01)

Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo
by: Michele Fantini, et al.
Published: (2019-03-01)

Vision improvement in a Taiwanese (Han Chinese) family with Leber's hereditary optic neuropathy
by: Hong-Zin Lin, et al.
Published: (2012-12-01)