Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

Viruses are promising anti-tumour therapeutics due to induction of an immune response and/or oncolytic activity. Here, Kalkavanet al. show that LCMV replicates in tumour cells, without inducing cell lysis, and that its anti-tumour activity is largely mediated by recruitment of interferon-producing m...

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Main Authors:	Halime Kalkavan, Piyush Sharma, Stefan Kasper, Iris Helfrich, Aleksandra A. Pandyra, Asmae Gassa, Isabel Virchow, Lukas Flatz, Tim Brandenburg, Sukumar Namineni, Mathias Heikenwalder, Bastian Höchst, Percy A. Knolle, Guido Wollmann, Dorothee von Laer, Ingo Drexler, Jessica Rathbun, Paula M. Cannon, Stefanie Scheu, Jens Bauer, Jagat Chauhan, Dieter Häussinger, Gerald Willimsky, Max Löhning, Dirk Schadendorf, Sven Brandau, Martin Schuler, Philipp A. Lang, Karl S. Lang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14447

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spelling	doaj-2452e9d8f1cb48cd9071ab5ededf8f252021-05-11T07:27:53ZengNature Publishing GroupNature Communications2041-17232017-03-018111410.1038/ncomms14447Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regressionHalime Kalkavan0Piyush Sharma1Stefan Kasper2Iris Helfrich3Aleksandra A. Pandyra4Asmae Gassa5Isabel Virchow6Lukas Flatz7Tim Brandenburg8Sukumar Namineni9Mathias Heikenwalder10Bastian Höchst11Percy A. Knolle12Guido Wollmann13Dorothee von Laer14Ingo Drexler15Jessica Rathbun16Paula M. Cannon17Stefanie Scheu18Jens Bauer19Jagat Chauhan20Dieter Häussinger21Gerald Willimsky22Max Löhning23Dirk Schadendorf24Sven Brandau25Martin Schuler26Philipp A. Lang27Karl S. Lang28Institute of Immunology, Medical Faculty, University Duisburg-EssenInstitute of Immunology, Medical Faculty, University Duisburg-EssenDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-EssenDepartment of Dermatology, West German Cancer Center, University Hospital Essen, University Duisburg-EssenInstitute of Immunology, Medical Faculty, University Duisburg-EssenInstitute of Immunology, Medical Faculty, University Duisburg-EssenDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-EssenDepartment of Dermatology/Allergology, Cantonal HospitalInstitute of Immunology, Medical Faculty, University Duisburg-EssenDepartment of Virology, Technical University of MunichDepartment of Virology, Technical University of MunichInstitute of Molecular Immunology/Experimental Oncology, München Klinikum rechts der Isar, Technical University MunichInstitute of Molecular Immunology/Experimental Oncology, München Klinikum rechts der Isar, Technical University MunichDivision for Virology, Medical University InnsbruckDivision for Virology, Medical University InnsbruckInstitute of Virology, Düsseldorf University Hospital, Heinrich Heine UniversityDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, University of Southern CaliforniaInstitute of Medical Microbiology and Hospital Hygiene, University of DüsseldorfInstitute of Medical Microbiology and Hospital Hygiene, University of DüsseldorfLudwig Institute for Cancer Research, University of OxfordDepartment of Gastroenterology, Hepatology and Infectious Diseases, University of DüsseldorfInstitute of Immunology (Charité - University Medicine Berlin)Department of Rheumatology and Clinical Immunology, Charité—University Medicine Berlin and German Rheumatism Research Center (DRFZ)Department of Dermatology, West German Cancer Center, University Hospital Essen, University Duisburg-EssenDepartment of Otorhinolaryngology, West German Cancer Center, University Hospital Essen, University Duisburg-EssenDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-EssenDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityInstitute of Immunology, Medical Faculty, University Duisburg-EssenViruses are promising anti-tumour therapeutics due to induction of an immune response and/or oncolytic activity. Here, Kalkavanet al. show that LCMV replicates in tumour cells, without inducing cell lysis, and that its anti-tumour activity is largely mediated by recruitment of interferon-producing monocytes.https://doi.org/10.1038/ncomms14447
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Halime Kalkavan Piyush Sharma Stefan Kasper Iris Helfrich Aleksandra A. Pandyra Asmae Gassa Isabel Virchow Lukas Flatz Tim Brandenburg Sukumar Namineni Mathias Heikenwalder Bastian Höchst Percy A. Knolle Guido Wollmann Dorothee von Laer Ingo Drexler Jessica Rathbun Paula M. Cannon Stefanie Scheu Jens Bauer Jagat Chauhan Dieter Häussinger Gerald Willimsky Max Löhning Dirk Schadendorf Sven Brandau Martin Schuler Philipp A. Lang Karl S. Lang
spellingShingle	Halime Kalkavan Piyush Sharma Stefan Kasper Iris Helfrich Aleksandra A. Pandyra Asmae Gassa Isabel Virchow Lukas Flatz Tim Brandenburg Sukumar Namineni Mathias Heikenwalder Bastian Höchst Percy A. Knolle Guido Wollmann Dorothee von Laer Ingo Drexler Jessica Rathbun Paula M. Cannon Stefanie Scheu Jens Bauer Jagat Chauhan Dieter Häussinger Gerald Willimsky Max Löhning Dirk Schadendorf Sven Brandau Martin Schuler Philipp A. Lang Karl S. Lang Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression Nature Communications
author_facet	Halime Kalkavan Piyush Sharma Stefan Kasper Iris Helfrich Aleksandra A. Pandyra Asmae Gassa Isabel Virchow Lukas Flatz Tim Brandenburg Sukumar Namineni Mathias Heikenwalder Bastian Höchst Percy A. Knolle Guido Wollmann Dorothee von Laer Ingo Drexler Jessica Rathbun Paula M. Cannon Stefanie Scheu Jens Bauer Jagat Chauhan Dieter Häussinger Gerald Willimsky Max Löhning Dirk Schadendorf Sven Brandau Martin Schuler Philipp A. Lang Karl S. Lang
author_sort	Halime Kalkavan
title	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_short	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_full	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_fullStr	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_full_unstemmed	Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
title_sort	spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regression
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-03-01
description	Viruses are promising anti-tumour therapeutics due to induction of an immune response and/or oncolytic activity. Here, Kalkavanet al. show that LCMV replicates in tumour cells, without inducing cell lysis, and that its anti-tumour activity is largely mediated by recruitment of interferon-producing monocytes.
url	https://doi.org/10.1038/ncomms14447
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Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

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