Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

Viruses are promising anti-tumour therapeutics due to induction of an immune response and/or oncolytic activity. Here, Kalkavanet al. show that LCMV replicates in tumour cells, without inducing cell lysis, and that its anti-tumour activity is largely mediated by recruitment of interferon-producing m...

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Main Authors: Halime Kalkavan, Piyush Sharma, Stefan Kasper, Iris Helfrich, Aleksandra A. Pandyra, Asmae Gassa, Isabel Virchow, Lukas Flatz, Tim Brandenburg, Sukumar Namineni, Mathias Heikenwalder, Bastian Höchst, Percy A. Knolle, Guido Wollmann, Dorothee von Laer, Ingo Drexler, Jessica Rathbun, Paula M. Cannon, Stefanie Scheu, Jens Bauer, Jagat Chauhan, Dieter Häussinger, Gerald Willimsky, Max Löhning, Dirk Schadendorf, Sven Brandau, Martin Schuler, Philipp A. Lang, Karl S. Lang
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14447

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https://doi.org/10.1038/ncomms14447

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