Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity

Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity

Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. HTT is subject to multiple post-translational modifications (PTMs) that regulate its cellular function. Mutating specific...

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Bibliographic Details
Main Authors: Fanny L. Lemarié, Nicholas S. Caron, Shaun S. Sanders, Mandi E. Schmidt, Yen T.N. Nguyen, Seunghyun Ko, Xiaohong Xu, Mahmoud A. Pouladi, Dale D.O. Martin, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Neurobiology of Disease
Subjects:
Palmitoylation
S-acylation
Huntingtin
Huntington disease
ZDHHC17
Acyl-protein thioesterase
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612100228X

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http://www.sciencedirect.com/science/article/pii/S096999612100228X

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