Depletion of Endogenous Zinc Stores Induces Oxidative Stress and Cell Death in Human Melanoma Cells
The role of intracellular free zinc and its chelation by TPEN (N,N,N’,N’-tetrakis(2–pyridylmethyl)ethylenediamine) was studied in Bowes human melanoma cells. The content of free Zn pools was determined by fluorescent probe Zinquin. Depletion of zinc triggered apoptosis confirmed by cell blebbing, ch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Karolinum Press
2004-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/47/2/0091/ |