CDK9-dependent RNA polymerase II pausing controls transcription initiation

CDK9-dependent RNA polymerase II pausing controls transcription initiation

Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a ‘multi-omics’ approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency...

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Bibliographic Details
Main Authors: Saskia Gressel, Björn Schwalb, Tim Michael Decker, Weihua Qin, Heinrich Leonhardt, Dirk Eick, Patrick Cramer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
CRISPR-Cas9
TT-seq
mNET-seq
CDK9
RNA polymerase II
Pausing
Online Access:https://elifesciences.org/articles/29736

Internet

https://elifesciences.org/articles/29736

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