RIG-1-Like Receptor Activation Synergizes With Intratumoral Alpha Radiation to Induce Pancreatic Tumor Rejection, Triple-Negative Breast Metastases Clearance, and Antitumor Immune Memory in Mice

RIG-1-Like Receptor Activation Synergizes With Intratumoral Alpha Radiation to Induce Pancreatic Tumor Rejection, Triple-Negative Breast Metastases Clearance, and Antitumor Immune Memory in Mice

Diffusing alpha-emitting radiation therapy (DaRT) employs intratumoral Ra-224-coated seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside the tumor. In immunogenic tumor models, DaRT was shown to activate systemic antitumor immunity. Agonists of the membrane-bo...

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Bibliographic Details
Main Authors: Vered Domankevich, Margalit Efrati, Michael Schmidt, Eran Glikson, Fairuz Mansour, Amit Shai, Adi Cohen, Yael Zilberstein, Elad Flaisher, Razvan Galalae, Itzhak Kelson, Yona Keisari
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
PolyIC
polyethylenimine
decitabine
radiotherapy
immunotherapy
alpha radiation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00990/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00990/full

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