Predictability of Genetic Interactions from Functional Gene Modules

Predictability of Genetic Interactions from Functional Gene Modules

Characterizing genetic interactions is crucial to understanding cellular and organismal response to gene-level perturbations. Such knowledge can inform the selection of candidate disease therapy targets, yet experimentally determining whether genes interact is technically nontrivial and time-consumi...

Full description

Bibliographic Details
Main Authors: Jonathan H. Young, Edward M. Marcotte
Format: Article
Language:English
Published: Oxford University Press 2017-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
epistasis
gene network
synthetic lethality
data mining
drug target
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.035915

Internet

http://g3journal.org/lookup/doi/10.1534/g3.116.035915

Similar Items