Organoid in colorectal cancer: progress and challenges

Organoid in colorectal cancer: progress and challenges

Abstract. Patient-derived tumor organoids (PDOs) currently represent important modeling tools in pre-clinical investigation of malignancies. Organoid cultures conserve the genetic and phenotypic characteristics of the original tumor and maintain its heterogeneity, allowing their application in many...

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Main Authors: Deng-Bo Ji, Ai-Wen Wu, Qiang Shi
Format: Article
Language:English
Published: Wolters Kluwer 2020-08-01
Series:Chinese Medical Journal
Online Access:http://journals.lww.com/10.1097/CM9.0000000000000882
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spelling doaj-23eccf1fbff44163989d027eb2f3dfb62020-12-02T08:00:06ZengWolters KluwerChinese Medical Journal0366-69992542-56412020-08-01133161971197710.1097/CM9.0000000000000882202008200-00011Organoid in colorectal cancer: progress and challengesDeng-Bo Ji0Ai-Wen Wu1Qiang Shi2Department of Gastrointestinal Surgery III, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing 100142, China.Department of Gastrointestinal Surgery III, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing 100142, China.Department of Gastrointestinal Surgery III, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute, Beijing 100142, China.Abstract. Patient-derived tumor organoids (PDOs) currently represent important modeling tools in pre-clinical investigation of malignancies. Organoid cultures conserve the genetic and phenotypic characteristics of the original tumor and maintain its heterogeneity, allowing their application in many research fields. PDOs derived from colorectal cancer (CRC) have been used for genetic modeling to investigate the function of driver genes. Some researchers have been exploring the value of CRC PDOs in chemotherapy, targeted therapy, and radiotherapy response prediction. The successful generation of PDOs derived from CRC could deepen our understanding of CRC biology and provide novel tools for cancer modeling, for realizing precision medicine by assessing specimens from individual patients ex vivo. The present review discusses recently reported advances in CRC PDOs and the challenges they face as pre-clinical models in CRC research.http://journals.lww.com/10.1097/CM9.0000000000000882
collection DOAJ
language English
format Article
sources DOAJ
author Deng-Bo Ji
Ai-Wen Wu
Qiang Shi
spellingShingle Deng-Bo Ji
Ai-Wen Wu
Qiang Shi
Organoid in colorectal cancer: progress and challenges
Chinese Medical Journal
author_facet Deng-Bo Ji
Ai-Wen Wu
Qiang Shi
author_sort Deng-Bo Ji
title Organoid in colorectal cancer: progress and challenges
title_short Organoid in colorectal cancer: progress and challenges
title_full Organoid in colorectal cancer: progress and challenges
title_fullStr Organoid in colorectal cancer: progress and challenges
title_full_unstemmed Organoid in colorectal cancer: progress and challenges
title_sort organoid in colorectal cancer: progress and challenges
publisher Wolters Kluwer
series Chinese Medical Journal
issn 0366-6999
2542-5641
publishDate 2020-08-01
description Abstract. Patient-derived tumor organoids (PDOs) currently represent important modeling tools in pre-clinical investigation of malignancies. Organoid cultures conserve the genetic and phenotypic characteristics of the original tumor and maintain its heterogeneity, allowing their application in many research fields. PDOs derived from colorectal cancer (CRC) have been used for genetic modeling to investigate the function of driver genes. Some researchers have been exploring the value of CRC PDOs in chemotherapy, targeted therapy, and radiotherapy response prediction. The successful generation of PDOs derived from CRC could deepen our understanding of CRC biology and provide novel tools for cancer modeling, for realizing precision medicine by assessing specimens from individual patients ex vivo. The present review discusses recently reported advances in CRC PDOs and the challenges they face as pre-clinical models in CRC research.
url http://journals.lww.com/10.1097/CM9.0000000000000882
work_keys_str_mv AT dengboji organoidincolorectalcancerprogressandchallenges
AT aiwenwu organoidincolorectalcancerprogressandchallenges
AT qiangshi organoidincolorectalcancerprogressandchallenges
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