Humoral immune responses mediate the development of a restrictive phenotype of chronic lung allograft dysfunction

Humoral immune responses mediate the development of a restrictive phenotype of chronic lung allograft dysfunction

Understanding the distinct pathogenic mechanisms that culminate in allograft fibrosis and chronic graft failure is key in improving outcomes after solid organ transplantation. Here, we describe an F1 → parent orthotopic lung transplant model of restrictive allograft syndrome (RAS), a particularly fu...

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Bibliographic Details
Main Authors: Keizo Misumi, David S. Wheeler, Yoshiro Aoki, Michael P. Combs, Russell R. Braeuer, Ryuji Higashikubo, Wenjun Li, Daniel Kreisel, Ragini Vittal, Jeffrey Myers, Amir Lagstein, Natalie M. Walker, Carol F. Farver, Vibha N. Lama
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-12-01
Series:JCI Insight
Subjects:
Pulmonology
Transplantation
Online Access:https://doi.org/10.1172/jci.insight.136533

Internet

https://doi.org/10.1172/jci.insight.136533

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