Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are important nitrogen donors for synthesis of glutamate, the main excitatory neurotransmitter in the brain. The glutamate carbon skeleton originates from the tricarboxylic acid (TCA) cycle intermediate α-ketoglutarate, while the...

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Bibliographic Details
Main Authors: Claudia Salcedo, Jens V. Andersen, Kasper Tore Vinten, Lars H. Pinborg, Helle S. Waagepetersen, Kristine K. Freude, Blanca I. Aldana
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
AD
astrocytes
BCAA
glutamate
glutamine
neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.736580/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.736580/full

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