In Silico Prediction Analysis of Idiotope-Driven T–B Cell Collaboration in Multiple Sclerosis

In Silico Prediction Analysis of Idiotope-Driven T–B Cell Collaboration in Multiple Sclerosis

Memory B cells acting as antigen-presenting cells are believed to be important in multiple sclerosis (MS), but the antigen they present remains unknown. We hypothesized that B cells may activate CD4+ T cells in the central nervous system of MS patients by presenting idiotopes from their own immunogl...

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Bibliographic Details
Main Authors: Rune A. Høglund, Andreas Lossius, Jorunn N. Johansen, Jane Homan, Jūratė Šaltytė Benth, Harlan Robins, Bjarne Bogen, Robert D. Bremel, Trygve Holmøy
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
idiotope
B cell
T cell
bioinformatics
immunoglobulin heavy variable
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01255/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01255/full

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