FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon

FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon

FHFs are known to regulate voltage-gated sodium channels (NaVs). Here, the authors compare the role of FHFs in cerebellar granule cell propagation, and find NaVs in the distal axon function independently of FHFs, allowing for faster inactivation rates and reducing energy demands during repetitive sp...

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Main Authors: Katarzyna Dover, Christopher Marra, Sergio Solinas, Marko Popovic, Sathyaa Subramaniyam, Dejan Zecevic, Egidio D’Angelo, Mitchell Goldfarb
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12895
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spelling doaj-23b209ca322947afa3adc05e33877f8c2021-05-11T11:16:13ZengNature Publishing GroupNature Communications2041-17232016-09-017111110.1038/ncomms12895FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axonKatarzyna Dover0Christopher Marra1Sergio Solinas2Marko Popovic3Sathyaa Subramaniyam4Dejan Zecevic5Egidio D’Angelo6Mitchell Goldfarb7Department of Biological Sciences, Hunter College of City UniversityDepartment of Biological Sciences, Hunter College of City UniversityBrain Connectivity Center, C. Mondino National Neurological InstituteDepartment of Cellular and Molecular Physiology, Yale University School of MedicineDepartment of Brain and Behavioral Science, University of PaviaDepartment of Cellular and Molecular Physiology, Yale University School of MedicineBrain Connectivity Center, C. Mondino National Neurological InstituteDepartment of Biological Sciences, Hunter College of City UniversityFHFs are known to regulate voltage-gated sodium channels (NaVs). Here, the authors compare the role of FHFs in cerebellar granule cell propagation, and find NaVs in the distal axon function independently of FHFs, allowing for faster inactivation rates and reducing energy demands during repetitive spiking.https://doi.org/10.1038/ncomms12895
collection DOAJ
language English
format Article
sources DOAJ
author Katarzyna Dover
Christopher Marra
Sergio Solinas
Marko Popovic
Sathyaa Subramaniyam
Dejan Zecevic
Egidio D’Angelo
Mitchell Goldfarb
spellingShingle Katarzyna Dover
Christopher Marra
Sergio Solinas
Marko Popovic
Sathyaa Subramaniyam
Dejan Zecevic
Egidio D’Angelo
Mitchell Goldfarb
FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
Nature Communications
author_facet Katarzyna Dover
Christopher Marra
Sergio Solinas
Marko Popovic
Sathyaa Subramaniyam
Dejan Zecevic
Egidio D’Angelo
Mitchell Goldfarb
author_sort Katarzyna Dover
title FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_short FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_full FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_fullStr FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_full_unstemmed FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
title_sort fhf-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description FHFs are known to regulate voltage-gated sodium channels (NaVs). Here, the authors compare the role of FHFs in cerebellar granule cell propagation, and find NaVs in the distal axon function independently of FHFs, allowing for faster inactivation rates and reducing energy demands during repetitive spiking.
url https://doi.org/10.1038/ncomms12895
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