Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury.

Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury.

BACKGROUND: Ventilator-induced lung injury (VILI) is characterized by vascular leakage and inflammatory responses eventually leading to pulmonary dysfunction. Vascular endothelial growth factor (VEGF) has been proposed to be involved in the pathogenesis of VILI. This study examines the inhibitory ef...

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Bibliographic Details
Main Authors: Maria A Hegeman, Marije P Hennus, Pieter M Cobelens, Annemieke Kavelaars, Nicolaas J G Jansen, Marcus J Schultz, Adrianus J van Vught, Cobi J Heijnen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3581459?pdf=render

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http://europepmc.org/articles/PMC3581459?pdf=render

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