N6-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression

N6-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression

Glioblastoma is among the most common malignant brain tumors and has a dismal prognosis due to the poor response to therapeutic regimens such as ionizing radiation and DNA-alkylating agents. In our study, we investigated the radiosensitizing activity of the N6-isopentenyladenosine (iPA), an naturall...

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Bibliographic Details
Main Authors: Giovanna Navarra, Cristina Pagano, Roberto Pacelli, Elvira Crescenzi, Elena Longobardi, Patrizia Gazzerro, Donatella Fiore, Olga Pastorino, Francesca Pentimalli, Chiara Laezza, Maurizio Bifulco
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
glioblastoma cells
iPA
apoptosis
STAT5a/b
RAD51
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01498/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01498/full

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