Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[<i>g</i>]quinazoline Derivatives (In Vitro)

Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[<i>g</i>]quinazoline Derivatives (In Vitro)

A series of 3-ethyl(methyl)-2-thioxo-2,3-dihydrobenzo[<i>g</i>]quinazolines (<b>1</b>–<b>17</b>) were synthesized, characterized, and evaluated in vitro for their antiangiogenesis VEGFR-2-targeting, antiproliferative, and antiapoptotic activities against breast MC...

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Bibliographic Details
Main Authors: Hatem A. Abuelizz, Mohamed Marzouk, Ahmed H. Bakheit, Hanem M. Awad, Maha M. Soltan, Ahmed M. Naglah, Rashad Al-Salahi
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
benzoquinazolines
MCF-7
HepG2
MTT assay
apoptosis
VEGFR-2
Online Access:https://www.mdpi.com/1420-3049/25/24/5944

Internet

https://www.mdpi.com/1420-3049/25/24/5944

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