Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis

Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis

Abstract Background Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we investigate the mechanism of PRL protection against bone loss in AIA and in monoarticular AIA (MAIA). Methods Joint inflammatio...

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Bibliographic Details
Main Authors: Maria G. Ledesma-Colunga, Norma Adán, Georgina Ortiz, Mariana Solís-Gutiérrez, Fernando López-Barrera, Gonzalo Martínez de la Escalera, Carmen Clapp
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Arthritis Research & Therapy
Subjects:
Hormones
Bone
Inflammation
Experimental arthritis
Osteoclasts
Synovial fibroblasts
Online Access:http://link.springer.com/article/10.1186/s13075-017-1290-4

Internet

http://link.springer.com/article/10.1186/s13075-017-1290-4

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