Anti-CD47 treatment enhances anti-tumor T-cell immunity and improves immunosuppressive environment in head and neck squamous cell carcinoma

Anti-CD47 treatment enhances anti-tumor T-cell immunity and improves immunosuppressive environment in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is considered as an immunosuppressive disease, with impaired tumor-infiltrating T lymphocytes and increased suppressive immune cells. The efficacy of CD47 antibodies in immune checkpoint therapy is not clearly understood in HNSCC. In this study, human ti...

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Bibliographic Details
Main Authors: Lei Wu, Guang-Tao Yu, Wei-Wei Deng, Liang Mao, Lei-Lei Yang, Si-Rui Ma, Lin-Lin Bu, Ashok B. Kulkarni, Wen-Feng Zhang, Lu Zhang, Zhi-Jun Sun
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
cd47
hnscc
immunotherapy
tissue microarrays
transgenic mouse model
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1397248

Internet

http://dx.doi.org/10.1080/2162402X.2017.1397248

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