Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma.

Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma.

Metastatic renal cell carcinoma (RCC) is an incurable disease in clear need of new therapeutic interventions. In early-phase clinical trials, the cytokine IFN-γ showed promise as a biotherapeutic for advanced RCC, but subsequent trials were less promising. These trials, however, focused on the indir...

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Bibliographic Details
Main Authors: Peirong Chen, Shoko Nogusa, Roshan J Thapa, Calvin Shaller, Heidi Simmons, Suraj Peri, Gregory P Adams, Siddharth Balachandran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3629199?pdf=render

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http://europepmc.org/articles/PMC3629199?pdf=render

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