Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules

Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules

Abstract Background Motor neuron degeneration or loss in the spinal cord is the characteristic phenotype of motor neuron diseases or spinal cord injuries. Being proliferative and located near neurons, astrocytes are considered ideal cell sources for regenerating neurons. Methods We selected and test...

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Bibliographic Details
Main Authors: An-Dong Zhao, Hua Qin, Meng-Li Sun, Kui Ma, Xiao-Bing Fu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Military Medical Research
Subjects:
Human astrocyte
Motor neuron
Reprogramming
Transdifferentiation
Conversion
Regeneration
Online Access:http://link.springer.com/article/10.1186/s40779-020-00271-7

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http://link.springer.com/article/10.1186/s40779-020-00271-7

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