Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing

Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing

The human GLI3 protein has a dual function as a transcriptional activator or repressor of hedgehog signaling, depending on the proteolytic processing forms of GLI3. In this study, we established a compound heterozygous GLI3 mutant human embryonic stem cell line (WAe001-A-20) through CRISPR/Cas9 edit...

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Bibliographic Details
Main Authors: Ruzhi Wei, Fang Yuan, Yuhang Wu, Yanli Liu, Kai You, Zhen Yang, Yan Chen, Anteneh Getachew, Ning Wang, Yingying Xu, Yuanqi Zhuang, Fan Yang, Yin-xiong Li
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118302319

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http://www.sciencedirect.com/science/article/pii/S1873506118302319

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