Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia

Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia

Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether silibinin (SB) treatment of monocytes from preeclamptic women could modulate NLRP1 and NLRP3 inflammasomes as well as TLR4/NF-κB path...

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Bibliographic Details
Main Authors: Mariana Leticia Matias, Virginia Juliani Gomes, Mariana Romao-Veiga, Vanessa Rocha Ribeiro, Priscila Rezeck Nunes, Graziela Gorete Romagnoli, Jose Carlos Peracoli, Maria Terezinha Serrao Peracoli
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
NLRP1/NLRP3 inflammasomes
NF-κB
monocytes
monosodium urate
preeclampsia
silibinin
Online Access:https://www.mdpi.com/1420-3049/24/8/1548

Internet

https://www.mdpi.com/1420-3049/24/8/1548

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