Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation

Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation

TNF receptor type 2 (TNFR2) has gained attention as a costimulatory receptor for T cells and as critical factor for the development of regulatory T cells (Treg) and myeloid suppressor cells. Using the TNFR2-specific agonist TNCscTNF80, direct effects of TNFR2 activation on myeloid cells and T cells...

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Bibliographic Details
Main Authors: Tobias Schmid, Lena Falter, Sabine Weber, Nils Müller, Konstantin Molitor, David Zeller, Dorothea Weber-Steffens, Thomas Hehlgans, Harald Wajant, Sven Mostböck, Daniela N. Männel
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
inflammation
immune regulation
costimulation
MDSC
TNFR2
regulatory T cell
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01471/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01471/full

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