Functional Characterization of Circulating Tumor Cells (CTCs) from Metastatic ER+/HER2− Breast Cancer Reveals Dependence on HER2 and FOXM1 for Endocrine Therapy Resistance and Tumor Cell Survival: Implications for Treatment of ER+/HER2− Breast Cancer

Functional Characterization of Circulating Tumor Cells (CTCs) from Metastatic ER+/HER2− Breast Cancer Reveals Dependence on HER2 and FOXM1 for Endocrine Therapy Resistance and Tumor Cell Survival: Implications for Treatment of ER+/HER2− Breast Cancer

Mechanisms of acquired endocrine resistance and late recurrence in patients with ER+/HER2− breast cancer are complex and not fully understood. Here, we evaluated mechanisms of acquired resistance in circulating tumor cells (CTCs) from an ER+/HER2− breast cancer patient who initially responded but la...

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Bibliographic Details
Main Authors: Sven Roßwag, Cristina L. Cotarelo, Klaus Pantel, Sabine Riethdorf, Jonathan P. Sleeman, Marcus Schmidt, Sonja Thaler
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
ER+/HER2− circulating tumor cells
endocrine therapy resistance
HER2-dependent FOXM1 expression
Online Access:https://www.mdpi.com/2072-6694/13/8/1810

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https://www.mdpi.com/2072-6694/13/8/1810

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