The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups

The contribution of cell surface FcRn in monoclonal antibody serum uptake from the intestine in suckling rat pups

The neonatal Fc Receptor (FcRn) in intestinal epithelium is the primary mechanism for transfer of maternal immunoglobulin G (IgG) from suckled milk to serum; but the factors contributing to the rapid uptake of IgG are poorly understood. These studies help to determine the contribution of cell-surfac...

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Bibliographic Details
Main Authors: Philip R Cooper, Connie M Kliwinski, Robert A Perkinson, Edwin eRagwan, John R Mabus, Gordon D Powers, Haimanti eDorai, Jill eGiles-Komar, Pamela J Hornby
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Pharmacology
Subjects:
IgG
uptake
bioavailability
cell surface receptor
FcRn
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00225/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00225/full

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