Inhibitory effects of total saponin from Korean Red Ginseng on [Ca2+]i mobilization through phosphorylation of cyclic adenosine monophosphate-dependent protein kinase catalytic subunit and inositol 1,4,5-trisphosphate receptor type I in human platelets

Inhibitory effects of total saponin from Korean Red Ginseng on [Ca2+]i mobilization through phosphorylation of cyclic adenosine monophosphate-dependent protein kinase catalytic subunit and inositol 1,4,5-trisphosphate receptor type I in human platelets

Background: Intracellular Ca2+([Ca2+]i) is a platelet aggregation-inducing molecule. Therefore, understanding the inhibitory mechanism of [Ca2+]i mobilization is very important to evaluate the antiplatelet effect of a substance. This study was carried out to understand the Ca2+-antagonistic effect o...

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Bibliographic Details
Main Authors: Jung-Hae Shin, Hyuk-Woo Kwon, Hyun-Jeong Cho, Man Hee Rhee, Hwa-Jin Park
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Journal of Ginseng Research
Subjects:
Ca2+-mobilization
inositol 1,4,5-trisphosphate receptor type I (Ser1756) phosphorylation
Panax ginseng
protein kinase A catalytic subunit (Thr197) phosphorylation
total saponin from Korean Red Ginseng
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845315000317

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http://www.sciencedirect.com/science/article/pii/S1226845315000317

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