Structural Variants as a Basis for Targeted Therapies in Hematological Malignancies

Structural Variants as a Basis for Targeted Therapies in Hematological Malignancies

Structural variants (SV) are changes in the genomic landscape that can alter gene expression levels and thus lead to disease development. The most common and best studied SVs in hematological malignancies are chromosomal translocations. Here, parts of two genes that are normally on different chromos...

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Bibliographic Details
Main Authors: Judith Schütte, Julia Reusch, Cyrus Khandanpour, Christine Eisfeld
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
structural variant (SV)
hematology
targeted therapy
chromosomal rearrangements
chromatin structure
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00839/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00839/full

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