Brown Spiders’ Phospholipases-D with Potential Therapeutic Applications: Functional Assessment of Mutant Isoforms

Brown Spiders’ Phospholipases-D with Potential Therapeutic Applications: Functional Assessment of Mutant Isoforms

Phospholipases-D (PLDs) found in <i>Loxosceles</i> spiders’ venoms are responsible for the dermonecrosis triggered by envenomation. PLDs can also induce other local and systemic effects, such as massive inflammatory response, edema, and hemolysis. Recombinant PLDs reproduce all of the de...

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Bibliographic Details
Main Authors: Thaís Pereira da Silva, Fernando Jacomini de Castro, Larissa Vuitika, Nayanne Louise Costacurta Polli, Bruno César Antunes, Marianna Bóia-Ferreira, João Carlos Minozzo, Ricardo Barros Mariutti, Fernando Hitomi Matsubara, Raghuvir Krishnaswamy Arni, Ana Carolina Martins Wille, Andrea Senff-Ribeiro, Luiza Helena Gremski, Silvio Sanches Veiga
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomedicines
Subjects:
<i>Loxosceles</i>
venom enzymes
phospholipases-D
mutant phospholipases-D
site-directed mutations
Online Access:https://www.mdpi.com/2227-9059/9/3/320

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https://www.mdpi.com/2227-9059/9/3/320

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