Application of an LC–MS/MS Method for the Simultaneous Quantification of Homovanillic Acid and Vanillylmandelic Acid for the Diagnosis and Follow-Up of Neuroblastoma in 357 Patients

Application of an LC–MS/MS Method for the Simultaneous Quantification of Homovanillic Acid and Vanillylmandelic Acid for the Diagnosis and Follow-Up of Neuroblastoma in 357 Patients

Homovanillic acid (HVA) and vanillylmandelic acid (VMA) are end-stage metabolites of catecholamine and are clinical biomarkers for the diagnosis of neuroblastoma. For the first time in Korea, we implemented and validated a liquid chromatography tandem mass spectrometry (LC–MS/MS) assay to measure ur...

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Bibliographic Details
Main Authors: Narae Hwang, Eunbin Chong, Hyeonju Oh, Hee Won Cho, Ji Won Lee, Ki Woong Sung, Soo-Youn Lee
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
mass spectrometry
validation
vanillylmandelic acid
homovanillic acid
neuroblastoma
urine
Online Access:https://www.mdpi.com/1420-3049/26/11/3470

Internet

https://www.mdpi.com/1420-3049/26/11/3470

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