A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I.

A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I.

During meiotic prophase I, double-strand breaks (DSBs) initiate homologous recombination leading to non-crossovers (NCOs) and crossovers (COs). In mouse, 10% of DSBs are designated to become COs, primarily through a pathway dependent on the MLH1-MLH3 heterodimer (MutLγ). Mlh3 contains an endonucleas...

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Bibliographic Details
Main Authors: Melissa Toledo, Xianfei Sun, Miguel A Brieño-Enríquez, Vandana Raghavan, Stephen Gray, Jeffrey Pea, Carolyn R Milano, Anita Venkatesh, Lekha Patel, Peter L Borst, Eric Alani, Paula E Cohen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008177

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https://doi.org/10.1371/journal.pgen.1008177

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