A Single Nucleotide Polymorphism in the Gene Promoter Affects Transcription and Influences Retinal Ganglion Cell Death
Pro-apoptotic Bax is essential for RGC (retinal ganglion cell) death. Gene dosage experiments in mice, yielding a single wild-type Bax allele, indicated that genetic background was able to influence the cell death phenotype. DBA/2J Bax +/− mice exhibited complete resistance to nerve damage after 2 w...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2010-03-01
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| Series: | ASN Neuro |
| Online Access: | https://doi.org/10.1042/AN20100003 |