Innate Immunity Derived Factors as External Modulators of the CXCL12 - CXCR4 Axis and Their Role in Stem Cell Homing and Mobilization

Innate Immunity Derived Factors as External Modulators of the CXCL12 - CXCR4 Axis and Their Role in Stem Cell Homing and Mobilization

<p>The &#945;-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G<sub>&#945;I</sub> protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has...

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Bibliographic Details
Main Author: Mariusz Z. Ratajczak, Karol Serwin, Gabriela Schneider
Format: Article
Language:English
Published: Ivyspring International Publisher 2013-01-01
Series:Theranostics
Online Access:http://www.thno.org/v03p0003.htm

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http://www.thno.org/v03p0003.htm

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