Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness

Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness

Abstract Background Bladder cancer progression has been associated with dysfunctional repair of double-strand breaks (DSB), a deleterious type of DNA lesions that fuel genomic instability. Accurate DSB repair relies on two distinct pathways, homologous recombination (HR) and classical non-homologous...

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Bibliographic Details
Main Authors: Christin Richter, Stephan Marquardt, Fanghua Li, Alf Spitschak, Nico Murr, Berdien A. H. Edelhäuser, George Iliakis, Brigitte M. Pützer, Stella Logotheti
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
E2F1
miR-888
APLF
Bladder cancer
Non-homologous end-joining
Online Access:http://link.springer.com/article/10.1186/s13046-019-1286-9

Internet

http://link.springer.com/article/10.1186/s13046-019-1286-9

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