Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats

Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats

Preclinical efforts to improve medical countermeasures against organophosphate (OP) chemical threat agents have largely focused on adult male models. However, age and sex have been shown to influence the neurotoxicity of repeated low-level OP exposure. Therefore, to determine the influence of sex an...

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Bibliographic Details
Main Authors: Eduardo A. González, Jonas J. Calsbeek, Yi-Hua Tsai, Mei-Yun Tang, Peter Andrew, Joan Vu, Elizabeth L. Berg, Naomi H. Saito, Danielle J. Harvey, Suangsuda Supasai, Gene G. Gurkoff, Jill L. Silverman, Pamela J. Lein
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Current Research in Toxicology
Subjects:
Cognitive deficits
Neurodegeneration
Neurogenesis
Neuroinflammation
Seizures
Sex differences
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X21000335

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http://www.sciencedirect.com/science/article/pii/S2666027X21000335

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