Modeling functional changes to Escherichia coli thymidylate synthase upon single residue replacements: a structure-based approach

Modeling functional changes to Escherichia coli thymidylate synthase upon single residue replacements: a structure-based approach

Escherichia coli thymidylate synthase (TS) is an enzyme that is indispensable to DNA synthesis and cell division, as it provides the only de novo source of dTMP by catalyzing the reductive methylation of dUMP, thus making it a key target for chemotherapeutic agents. High resolution X-ray crystallogr...

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Bibliographic Details
Main Author: Majid Masso
Format: Article
Language:English
Published: PeerJ Inc. 2015-01-01
Series:PeerJ
Subjects:
Computational mutagenesis
Knowledge-based potential
Variant function prediction
Structure–function relationships
Machine learning
Thymidylate synthase
Online Access:https://peerj.com/articles/721.pdf

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https://peerj.com/articles/721.pdf

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