Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

Cerebrovascular dysfunctions appear to contribute to Alzheimer's disease (AD) pathogenesis and the associated cognitive decline. Recently, it has been suggested that statins could be beneficial to AD patients independently from their cholesterol-lowering effects. Using 10 month-old amyloid prec...

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Bibliographic Details
Main Authors: Xin-Kang Tong, Nektaria Nicolakakis, Priscilla Fernandes, Brice Ongali, Jonathan Brouillette, Rémi Quirion, Edith Hamel
Format: Article
Language:English
Published: Elsevier 2009-09-01
Series:Neurobiology of Disease
Subjects:
Amyloid-beta
Statin
Memory
Cholinergic
Oxidative stress
Cerebral blood vessels
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001387

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http://www.sciencedirect.com/science/article/pii/S0969996109001387

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