Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors.

Serotonergic ligands have proven effective drugs in the treatment of migraine, pain, obesity, and a wide range of psychiatric and neurological disorders. There is a clinical need for more highly 5-HT2 receptor subtype-selective ligands and the most attention has been given to the phenethylamine clas...

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Bibliographic Details
Main Authors: Vignir Isberg, James Paine, Sebastian Leth-Petersen, Jesper L Kristensen, David E Gloriam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3820707?pdf=render