Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

<p>Abstract</p> <p>Background</p> <p>Glucagon is an important hormone in the regulation of glucose homeostasis, particularly in the maintenance of euglycemia and prevention of hypoglycemia. In type 2 Diabetes Mellitus (T2DM), glucagon levels are elevated in both the fas...

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Bibliographic Details
Main Authors: Molloy Mark P, Zavadoski William J, Wei Ru, Xi Li, McDowell Michael T, MacDougall Margit L, Yang Jianxin, Baker John D, Kuhn Max, Cabrera Over, Treadway Judith L
Format: Article
Language:English
Published: BMC 2011-06-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/12/281

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http://www.biomedcentral.com/1471-2164/12/281

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