Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine-to-tyrosine ratios

Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine-to-tyrosine ratios

Higher serum neopterin concentrations and kynurenine-to-tryptophan (Kyn/Trp) ratios are associated with increased mortality in patients with coronary artery disease (CAD). Preferentially, Th1-type cytokine interferon-γ stimulates tryptophan breakdown and neopterin production by GTP cyclohydrolase I...

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Bibliographic Details
Main Authors: Mangge Harald, Schnedl Wolfgang J., Schröcksnadel Sebastian, Geisler Simon, Murr Christian, Fuchs Dietmar
Format: Article
Language:English
Published: De Gruyter 2013-06-01
Series:Pteridines
Subjects:
coronary artery disease
neopterin
phenylalanine
phenylalanine hydroxylase
tetrahydrobiopterin
Online Access:https://doi.org/10.1515/pterid-2013-0002

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