Role of lipotoxicity in insulin resistance in subtotally nephrectomized mouse model

Chronic kidney disease (CKD) is associated with a large range of metabolic alterations among which insulin resistance and dyslipidemia. We hypothesize that a phenomenon of lipotoxicity and ectopic fat redistribution could be responsible for the insulin-resistance associated to CKD. C57BL/6 mice unde...

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Bibliographic Details
Main Authors: Laetitia Koppe, Caroline Pelletier, Roxane Vella, Denis Fouque, Fitsum Guebre-Egziahber, Christophe Soulage
Format: Article
Language:English
Published: The Korean Society of Nephrology 2012-06-01
Series:Kidney Research and Clinical Practice
Online Access:http://www.sciencedirect.com/science/article/pii/S221191321200486X