Altered islet morphology but normal islet secretory function in vitro in a mouse model with microvascular alterations in the pancreas.

BACKGROUND:Our previous studies have shown that signal transducer and activator of transcription 3 (STAT3) signaling is important for the development of pancreatic microvasculature via its regulation of vascular endothelial growth factor-A (VEGF-A). Pancreas-specific STAT3-KO mice exhibit glucose in...

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Bibliographic Details
Main Authors: Elena Kostromina, Xiaorui Wang, Weiping Han
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3726616?pdf=render